Abstract Background Contrasting to the well documented tyrosine kinase inhibitor (TKI)-induced hypertension, little is known on their intrinsic vasomotor effects.We investigated the vasomotor effects of sorafenib, a widely used multikinase inhibitor in the treatment of hepatocellular and renal cell carcinoma and tested the hypothesis that sildenafi
Dynamic RNA Regulation in the Brain Underlies Physiological Plasticity in a Hibernating Mammal
Hibernation is a physiological and behavioral phenotype that minimizes energy expenditure.Hibernators cycle between profound depression and rapid hyperactivation of multiple physiological processes, challenging our concept of mammalian homeostasis.How the hibernator orchestrates and survives these extremes while maintaining cell to organismal viabi
Numerical method application to the prediction of noise of the internal combustion engine exhaust system
A numerical method for the prediction of noise of the internal combustion engine exhaust system is presented in the paper.The engine has been modelled by the system of Clothes Steamer nonlinear differential equations while the exhaust system has been modelled by linear differential equations.The correlation between the engine mathematical models an